Causes of failure of Classical Swine Fever immunity

When raising pigs, we need to strictly do a good job of vaccination against various epidemics according to the immunization procedure. Especially for common infectious diseases such as classical swine fever, if immunization is not done well, it is very disadvantageous to the overall development of the pig herd. However, when many people immunize pigs against classical swine fever, there is often a failure of classical swine fever immunity. So what is the reason for the failure of classical swine fever immunity? The following editor will give you a brief introduction, let's have a look!

1. The immunization procedure is unreasonable.

Unreasonable immunization procedure is one of the main reasons for the failure of classical swine fever immunization. At present, there are generally three kinds of immunization procedures in pig farms in China. The first is to gather boars and sows to immunize swine fever vaccine twice a year. Although this method is simple, it can control classical swine fever quickly. But it will have a certain impact on pregnant sows. The second is to co-immunize sows and piglets, mainly early weaning, which can lead to immune failure if sows have reproductive disorders. Finally, it is mainly advanced immunization, these three immunization methods have some points and shortcomings, we should make a reasonable immunization plan according to the actual situation of the pig farm to avoid immune failure.

2. Maternal antibody interference

For newborn piglets, the sow's own immunity to classical swine fever antibody is very important, but it can also affect vaccination. When there are maternal antibodies in piglets, the antibodies will neutralize the vaccine, resulting in an inability to produce an immune response, resulting in immune failure. However, if the maternal antibodies of piglets disappear completely, it may lead to piglets being infected with the disease. Therefore, we should pay attention to choose an appropriate time for immunization to avoid being affected by maternal antibodies. If the antibody level of sows is still very low after repeated inoculation, it should be eliminated in time.

3. Poor quality of vaccine.

The quality of the vaccine will directly affect the immune effect. When we choose the vaccine, we should not only pay attention to the regular manufacturers, but also pay attention to the shelf life and vaccine status and other information. When preserving or transporting the vaccine, it should be placed at minus 15 degrees Celsius, and should not be frozen and thawed repeatedly, otherwise it will have a great impact on the quality and effectiveness of the vaccine. After diluting the vaccine, be careful to use up all of it within two hours to avoid losing its effect. When disinfecting the needle, we should pay attention to the concentration of the disinfectant should not be too high to avoid killing the classical swine fever vaccine. Finally, in immunization, we should take one pig and one needle as the principle to prevent and cure the emergence of virus-carrying injection, which will not only lead to vaccine immunization failure, but also may spread the epidemic.

4. Other factors

Classical swine fever vaccine is also affected by a variety of antiviral drugs. Therefore, before and after vaccination, we should pay attention to the use of antiviral drugs. For example, hormones such as streptomycin and neomycin will affect the formation of antibodies in pigs, resulting in a decline in immune effect. In addition, genetic factors will also inhibit the immune response of the body, different breeds of pigs, the immune response is different. In addition, the environment in the pigsty will also affect the immune effect, if the pig is stressed, then it will also affect the immune antibody.

The above is a brief introduction to the reasons for the failure of classical swine fever immunity. That's all for today's introduction. This article is for reference only. I hope it can help you all.