Efficacy and function of Evodia rutaecarpa

The treatment of diseases also requires very good drugs, and only in this way can they be of great help to the improvement of the diseases. there are many kinds of drugs common in life, especially some Chinese herbal medicines, which are classified. Therefore, when choosing such drugs, we also need to pay attention to which diseases can be treated so that when they are used, they will not endanger their own health. What are the efficacy and effects of Evodia rutaecarpa?

The efficacy of Evodia rutaecarpa

Relieve cold and relieve pain

Including warming the meridian, including warming the meridian, for headache, abdominal pain, dysmenorrhea and warming the liver meridian when the meridian is cold; where the stomach is cold or the spleen and stomach is cold, it can be widely used. Used for the syndrome of cold stagnation and pain in the liver and pulse. This product dispels bitter diarrhea, heat and dispels cold. It not only dispels the cold evil of the liver meridian, but also relieves the stagnation of the liver meridian. It is an important medicine for the treatment of pain caused by cold qi stagnation of the liver. To treat cold hernia and abdominal pain, it is often compatible with fennel, toosendan seed, wood incense and so on, such as Daoqi decoction. For the treatment of Jueyin headache, it is often used with ginseng and ginger, such as Wuzhuyu decoction. Treatment of dysmenorrhea caused by Chong Ren deficiency cold and blood stasis can be used with Cinnamomum twig, Angelica sinensis and Ligusticum chuanxiong, such as Wenjing decoction. If cold and wet beriberi is swollen and painful, or flush into the abdomen, it is often used with papaya, perilla leaf, betel nut and so on, such as Ji Ming San. It has the effect of invigorating qi slightly, but it is partial to relieve pain.

Stop vomiting

Used for stomach cold vomiting syndrome. This product has the function of warming and dispelling cold, reducing adverse events and stopping vomiting. For the treatment of epigastric cold pain due to deficiency and cold in the middle jiao, vomiting is acid, and it is often used with ginseng and ginger, such as Wuzhuyu decoction. For the treatment of external cold and internal invasion, stomach loss and vomiting, it can be used with Pinellia ternata and ginger. It is often compatible with Coptis chinensis, which is used to clear stomach heat, to treat vomiting caused by stomach heat or liver depression.

Assist yang and stop diarrhea

It is bitter, can be dry and wet, and is used for diarrhea, diarrhea, deficiency cold diarrhea syndrome. This product can warm the spleen and kidney, help yang and stop diarrhea, for the treatment of spleen and kidney yang deficiency, five more diarrhea commonly used with psoralen, nutmeg, Schisandra, such as Sishen pills. Yang deficiency, cold diarrhea, it tonifying yang, dispelling cold and relieving pain, dryness and dampness, is the most suitable.

Soothing the liver and regulating qi

Hard and warm, enter the liver meridian, use it to soothe the liver qi to relieve cold and relieve depression, so it can be used for various diseases caused by liver qi stagnation, "Materia Medica read": "Evodia, hard but warm, fragrant and dry, is the main part of the liver." Its nature is not depressed the fastest, extremely able to spread depression, so the treatment of liver qi stagnation, cold entrenched, so that abdominal pain, hernia and other diseases, or disease evil go down to the extreme and up. It is for vomiting and swallowing acid chest full of diseases, all of which can be treated. "

Warming spleen and promoting dampness

Taste Xin can be scattered, taste bitter can be dry, sexual temperature can dispel cold, so it can be used for various diseases caused by cold and temperature, Compendium of Materia Medica: "Cornus officinalis, pungent heat can disperse, can be wet; bitter heat can dry, can be firm." Therefore, all the diseases treated are based on the work of dispelling dryness and dampness in the cold and temperature. "

The function of Evodia rutaecarpa

Antihypertensive effect

After filtrating the steamed liquid, decoction and granule of Evodia rutaecarpa, normal rabbits, normal dogs and experimental renal hypertensive dogs were injected intravenously at a dose of 2-4g crude medicine per dog, which all had obvious antihypertensive effect and lasted for a long time. Generally, it lasted for more than 3 hours, and the hypotensive range of the decoction was smaller than that of intravenous injection. The antihypertensive effect of Evodia rutaecarpa is mainly to dilate the peripheral vessels and reduce the resistance of the peripheral vessels, which is related to the release of histamine.

Effect on the digestive system

The study shows that the Evodia rutaecarpine contained in Evodia rutaecarpa is bitter, which has the effect of tonifying the stomach, and the volatile oil it contains has the effect of fragrant and invigorating the stomach. The methanol extract of Evodia rutaecarpa has the effect of anti-water immersion stress ulcer in rats, and the water decoction also has the effect of anti-hydrochloric acid gastric ulcer and indomethacin plus ethanol gastric ulcer, and has a tendency to inhibit the formation of water immersion stress and ligation pyloric ulcer. Evodia has bidirectional effect on the activity of isolated small intestine, excited at low concentration and inhibited spontaneous contraction at high concentration, which can antagonize the excitatory effects of nicotine, phentolamine, acetylcholine, histamine, barium chloride, phentolamine and reserpine on isolated small intestine. It could also antagonize the inhibitory effect of hexamethamine, atropine and epinephrine on isolated small intestine, but could not antagonize the inhibitory effect of diphenhydramine, opium poppy, verapamil and meisan on isolated rabbit small intestine.

Effect on uterine smooth muscle

The parasympathetic component of Evodia rutaecarpa can relax the uterus in vitro, while the residual solution without sympathomimetic component can excite the uterus of rats and antagonize the relaxing effect of hydroxyforlin. The ingredients that excite the uterus are dehydroevodia rutaecarpa, Evodia rutaecarpa and rutamine. Dehydroevodia may be a serotonin receptor agonist and its uterine excitatory effect can be blocked by dimethyl ergoxine but not by atropine.

Effects on the central nervous system

It is mainly for analgesic effect, and its analgesic components are Evodia rutaecarpa, Fructus evodiae, isoevodium rutaecarpa and Evodia lactone. Intravenous injection of 10% ethanol extract of Evodia rutaecarpa can not only increase the body temperature of rabbits, but also increase the threshold of oral muscle group contracture caused by electrical stimulation of rabbit tooth pulp, and its effect intensity is similar to that of aminopyrine. Evodia rutaecarpa decoction 5g/kg and 20g/kg could significantly delay the pain response time and could not disappear for 2.5 hours. Oral Evodia rutaecarpa has antiemetic effect, which can be strengthened when taken with ginger. However, it was also reported that Evodia rutaecarpa decoction and acetone extract had no antiemetic effect on vomiting caused by 4% copper sulfate.

Effects on cardiovascular system

Evodia rutaecarpa alcohol-water extract 0.03-0. 24g/kg produced a dependent pressor effect and increased diaphragm contractility in anesthetized cats, but tetraethylamine could not antagonize it. Intraperitoneal injection of conscious rats also caused hypertension. Bilateral nephrectomy, phentolamine or propranolol significantly reduced the pressor effect. The results showed that Evodia rutaecarpa decoction, granule and distillate had significant antihypertensive effect by intravenous injection and intragastric administration, and the antihypertensive duration was longer, generally more than 3 hours, and had no significant effect on heart rate during hypotension, but the antihypertensive effect of intramuscular injection was very weak, and it also had antihypertensive effect on experimental renal hypertensive dogs and normal rabbits. Licorice decoction can lose the antihypertensive effect of Evodia rutaecarpa. Evodia rutaecarpa has no blocking effect on ganglion, but can antagonize the pressor response induced by epinephrine, norepinephrine and vasopressin. It has been reported that the cardiovascular effect of alcohol water extract of Evodia rutaecarpa is produced by stimulating α-receptor and β-receptor.

Drive Ascaris lumbricoides

The alcohol extract of Evodia rutaecarpa has a significant effect on Ascaris lumbricoides in vitro, and also on earthworms and leeches.

Antibacterial

The decoction of Evodia rutaecarpa had strong inhibitory effect on Vibrio cholerae (Agar trenching plate method), 10% of the water extract had inhibitory effect on flocculent dermatophytes in the test tube, and 1:3 water extract had different degrees of inhibition on 11 kinds of skin fungi, such as Trichophyton Auduoni.

Other

10% alcohol extract of Evodia plants, injected 0.5-1.0 ml into rabbits, blood pressure increased briefly and slightly, breathing was slightly excited, increased carotid blood flow, 0.1% isoevodia hydrochloride 0.2 ml / 1 kg intravenous injection rabbit blood pressure had no significant change, respiration slightly increased, 0.02-0.1% had no obvious effect on isolated frog heart, frog lower limb vascular perfusion. In general, it is not obvious, it expands first and then contracts; for the isolated rabbit intestine, it is paralyzed after short oath. It began to excite the isolated rabbit uterus, and the toxicity of Evoxine was low. The half-lethal dose to mice was 705mg / 1kg subcutaneously and 135mg / 1kg intravenously. The components of Evodia rutaecarpa, such as Evodia rutaecarpa, Evodia Rutamine, the decomposition product of Evodia rutaecarpa, has a strong effect on uterine contraction. Evodia rutaecarpa has anti-Columbia SK virus effect in mice.

The alkaloids obtained from Exanthoxgloides are similar to those of Fungi. It can enhance the effect of epinephrine, improve the excitability of spinal cord, relax the smooth muscle of small intestine and increase the tension of striated muscle, which is similar to that of ephedra in some aspects.

The ingredients that excite the uterus are dehydroevodia rutaecarpa, Evodia rutaecarpa and rutamine. Dehydroevodia may be a serotonin receptor agonist and its uterine excitatory effect can be blocked by dimethyl ergoxine but not by atropine.

Effects on the central nervous system

It is mainly for analgesic effect, and its analgesic components are Evodia rutaecarpa, Fructus evodiae, isoevodium rutaecarpa and Evodia lactone. Intravenous injection of 10% ethanol extract of Evodia rutaecarpa can not only increase the body temperature of rabbits, but also increase the threshold of oral muscle group contracture caused by electrical stimulation of rabbit tooth pulp, and its effect intensity is similar to that of aminopyrine. Evodia rutaecarpa decoction 5g/kg and 20g/kg could significantly delay the pain response time and could not disappear for 2.5 hours. Oral Evodia rutaecarpa has antiemetic effect, which can be strengthened when taken with ginger. However, it was also reported that Evodia rutaecarpa decoction and acetone extract had no antiemetic effect on vomiting caused by 4% copper sulfate.

Effects on cardiovascular system

Evodia rutaecarpa alcohol-water extract 0.03-0. 24g/kg produced a dependent pressor effect and increased diaphragm contractility in anesthetized cats, but tetraethylamine could not antagonize it. Intraperitoneal injection of conscious rats also caused hypertension. Bilateral nephrectomy, phentolamine or propranolol significantly reduced the pressor effect. The results showed that Evodia rutaecarpa decoction, granule and distillate had significant antihypertensive effect by intravenous injection and intragastric administration, and the antihypertensive duration was longer, generally more than 3 hours, and had no significant effect on heart rate during hypotension, but the antihypertensive effect of intramuscular injection was very weak, and it also had antihypertensive effect on experimental renal hypertensive dogs and normal rabbits. Licorice decoction can lose the antihypertensive effect of Evodia rutaecarpa. Evodia rutaecarpa has no blocking effect on ganglion, but can antagonize the pressor response induced by epinephrine, norepinephrine and vasopressin. It has been reported that the cardiovascular effect of alcohol water extract of Evodia rutaecarpa is produced by stimulating α-receptor and β-receptor.

Drive Ascaris lumbricoides

The alcohol extract of Evodia rutaecarpa has a significant effect on Ascaris lumbricoides in vitro, and also on earthworms and leeches.

Antibacterial

The decoction of Evodia rutaecarpa had strong inhibitory effect on Vibrio cholerae (Agar trenching plate method), 10% of the water extract had inhibitory effect on flocculent dermatophytes in the test tube, and 1:3 water extract had different degrees of inhibition on 11 kinds of skin fungi, such as Trichophyton Auduoni.

Other

10% alcohol extract of Evodia plants, injected 0.5-1.0 ml into rabbits, blood pressure increased briefly and slightly, breathing was slightly excited, increased carotid blood flow, 0.1% isoevodia hydrochloride 0.2 ml / 1 kg intravenous injection rabbit blood pressure had no significant change, respiration slightly increased, 0.02-0.1% had no obvious effect on isolated frog heart, frog lower limb vascular perfusion. In general, it is not obvious, it expands first and then contracts; for the isolated rabbit intestine, it is paralyzed after short oath. It began to excite the isolated rabbit uterus, and the toxicity of Evoxine was low. The half-lethal dose to mice was 705mg / 1kg subcutaneously and 135mg / 1kg intravenously. The components of Evodia rutaecarpa, such as Evodia rutaecarpa, Evodia Rutamine, the decomposition product of Evodia rutaecarpa, has a strong effect on uterine contraction. Evodia rutaecarpa has anti-Columbia SK virus effect in mice.

The alkaloids obtained from Exanthoxgloides are similar to those of Fungi. It can enhance the effect of epinephrine, improve the excitability of spinal cord, relax the smooth muscle of small intestine and increase the tension of striated muscle, which is similar to that of ephedra in some aspects.