The anti-tumor effect of mulberry yellow may be stronger than that of Ganoderma lucidum.

The anti-tumor effect of mulberry yellow may be stronger than that of Ganoderma lucidum.

Zhao Guoping

Hangzhou held two Sanghuang seminars in half a year.

Half a year after the Hangzhou Association of Science and Technology held the "Cross-Strait Ganoderma lucidum Sang Huang Seminar" on October 17, 2013, another national-scale "Cross-Strait Mulberry Yellow Research and Industrial Development Seminar", hosted by the Chinese Society of Fungi, was held in Hangzhou a few days ago. In a short period of half a year, seminars with basically the same content and a great increase in the number of participants were held in the same city, which shows the fact that Sang Huang has become popular rapidly in the field of edible and medicinal fungi in China.

This still seems to be a market upsurge. Since 2010, the famous time-honored brands of traditional Chinese medicine in Hangzhou, such as Hu Qingyu Tang, Fang Huichun Tang, Ye Zude Tang, Wan Chengzhi Tang, Zhang Tontai, and Beijing Tongren Hall, have been out of stock again and again for a long time, and the evaluation given by tumor patients seems to be better than that of Ganoderma lucidum on the whole. Starting from this year, a group of patients with thyroid nodules and thyroid nodule adenomas came to the time-honored brand of traditional Chinese medicine to look for wild mulberry yellow. The wild mulberry resources in the areas around Hangzhou have long been exhausted.

The formation of mulberry fever in Hangzhou is inseparable from the guidance of the media. However, industry insiders point out that today's consumers are very rational, and the media alone will not be able to form a climate. Behind the mulberry yellow fever, it must be that mulberry yellow has brought a really credible effect to the users, and there is no way to replace this effect.

Hangzhou Hu Qingyu Tangguo medicine number is a place where citizens buy mulberry yellow more often, so there are often typical cases related to mulberry yellow. Last week, a consumer dressed as a sanitation worker came to the counter, probably a sanitation worker along Hefang Street. She said that a month ago, she had a 6-centimeter thyroid nodule on her neck. After eating mulberry for a month, the nodule used to feel hard, but now it has become much softer and 1 centimeter smaller. We asked if there was a phone number for the consumer, and they said no. We'll find out when the customer comes next time.

According to the analysis of the old pharmacist, in ancient times, Ganoderma lucidum was roughly divided into five kinds according to color: black Ganoderma lucidum in the kidney, White Ganoderma lucidum in the lung, Huangzhi in the spleen, Ganoderma lucidum in the heart, Ganoderma lucidum in the liver, Sang Huang in the range of Huangzhi, invigorating the spleen, and in traditional Chinese medicine, the spleen is unified with blood, that is to say, Sanghuang is divided into blood, which is consistent with the record of "Drug Nature Theory". Tumors all have blood vessels, mulberry yellow into the blood, promoting blood circulation and removing blood stasis, soft and scattered knots, which may be the pharmacological mechanism of softening thyroid nodules.

In 2010, this magazine began to promote mulberry. In view of the fact that wild mulberry, which has been used in China since the Tang Dynasty, has formed a mature industry in Japan and South Korea, there is no movement here. After we reported it, there was almost no social response. At that time, we were lonely. In a short period of 4 years, the development of Sanghuang in our province is greatly beyond our expectations.

What makes us feel more gratified is that Sanghuang may really be a wild medicinal fungus which is safer and more effective for tumor patients than Ganoderma lucidum. Although thousands of foreign papers say that mulberry is better than Ganoderma lucidum. However, we have not seen any clinical control reports in China. We only heard from the time-honored brand of traditional Chinese medicine that almost all tumor patients are designated to buy wild mulberry yellow.

The position of Sanghuang in South Korea and Japan is like Cordyceps sinensis in us.

Chen Ruoyun, a researcher at the Institute of Medicine of the Chinese Academy of Medical Sciences and an expert on Ganoderma lucidum in China, said that Sang Huang, also known as Sangchen, Mulberry ear, or Hu Sunyan in ancient China, is a medicinal fungus with high economic value in Japan and South Korea. The name of Sanghuang first came from the Theory of Medicinal Properties written by Zhen Quan in the early Tang Dynasty in 1380. Its efficacy is recorded as: "to treat women's avalanche, blood clotting after birth, postpartum hemagglutination, men's ecstasy, and to treat hemoptysis and red blood." Later, it was also seen in the world's earliest official pharmacopoeia, newly revised Materia Medica, promulgated by the Tang Dynasty, and the Compendium of Materia Medica written by Li Shizhen in the Ming Dynasty also recorded the curative effect of mulberry yellow.

Professor Wu Shenghua, a researcher at the Taiwan Museum of Natural Science, is an expert in Sanghuang studies. At the "Symposium on Mulberry Yellow Research and Industrial Development between the two sides of the Taiwan Strait" held on the 14th of last month, he said, "the dropping of atomic bombs in World War II led to an increase in cancer cases in Hiroshima and Nagasaki regions. however, it was found that residents evacuated to Nagasaki Island were in good health and suffered less cancer because they were in good health and suffered less cancer, and began to study the traditional medicinal fungus Sang Huang, which is rich in female Island. In 1968, Japanese scholars published the anticancer effect of mulberry yellow, transplanted sarcoma 180 cancer cells into experimental mice, and then injected hot water extracts of more than 10 kinds of mushrooms into the abdomen of mice to compare the effect of these mushrooms on inhibiting the proliferation of cancer cells. Results the tumor inhibition rate of Sanghuang was as high as 96.7%, which was the highest among the tested mushroom species. Japan took the lead in discovering the magical anti-cancer effect of mulberry yellow with modern science. How can South Korea, which regards mulberry yellow as a national herb, lag behind others? South Korea has fully supported the research and development of Sanghuang since 1984. Ten years later, the Korean government approved Sanghuang mycelium as an anti-cancer adjuvant. Up to now, most of the research papers on the pharmacology and medicine of Sanghuang in the world have been put forward by Korean scholars. Sanghuang is like the Cordyceps sinensis of Chinese mainland in Japan and Korea. "

The Sanghuang information we found on the Internet

From the data, we can see that Sanghuang is really hot abroad.

According to Chinanews.com on August 3, 2006, the overseas edition of People's Daily, entitled "Scientific Research found that Pleurotus ostreatus helps fight Cancer" and "British Chinese scientists found that Pleurotus ostreatus helps treat prostate cancer", reported the new discovery of Pleurotus ostreatus: a study by Chinese scientists at Boston University School of Medicine in England found that the extract of Pleurotus ostreatus was added to the cancer drug "doxorubicin". It can improve the efficacy of this drug in the treatment of prostate cancer.

Chen Changyan, the Chinese scientist in charge of the study, said in the British Cancer Research: "Studies have shown that Pleurotus ostreatus has a certain effect on cancer cell activity in patients with prostate cancer." The researchers added the extract of Pleurotus ostreatus to a small dose of anticancer drugs (because large doses may have overshadowed the properties of Pleurotus ostreatus), and found that the effect was equivalent to that of a large dose of anticancer drugs without Pleurotus ostreatus, which could effectively kill cancer cells without damage to normal cells. it's also less toxic. Lewis, a British cancer research group, said: "there is evidence that Pleurotus ostreatus extract mixed with individual cancer drugs can slow the growth of prostate tumors."

According to Xu Zhengkui's "Sang Huang: the King of Anticancer Fungi, there is no mature industrial chain in China" in the Pharmaceutical Economic Daily on November 26, 2007, it is believed that the anti-tumor effect of Sang Huang is stronger than that of Ganoderma lucidum. Sang Huang is regarded as the "king of anticancer fungi".

However, contemporary scholars have recognized that Phellodendron chinense is the most effective medicinal fungus in the field of biological anti-tumor, and it has become a hot spot in the field of medicinal fungi.

Experiments have confirmed that mulberry yellow has an extraordinary ability to activate the human immune system. It has been proved by various animal and human experiments that Phellodendron chinense can increase the activation degree of NK cells by 2 times, T cells by 3 times, B cells by 129 times and macrophages by 3 to 5 times (the above cells are called white blood cells, which are disease-resistant cells of the human body. The higher the activity of these cells, the better the patient's own immune function). By activating the body's immune system, Sanghuang uses the body's own immune cells to attack tumor cells, thus avoiding the side effects of antineoplastic drugs or radiation therapy. If Sanghuang is used in combination with antineoplastic drugs or radiotherapy, side effects such as loss of appetite, high fever, vomiting and hair loss can be reduced. For patients undergoing radiotherapy and chemotherapy after operation, taking Sanghuang can restore and strengthen the immune system, so as to prevent tumor recurrence or inhibit residual tumor cell metastasis.

Let's take a look at some clinical data.

Researcher: mountain name sign three

Research unit: Xitiao Central Hospital in Japan

Patients: 8 patients with advanced gastric tumor, 5 patients with lung tumor, 8 patients with liver tumor, 4 patients with esophageal tumor and 5 patients with rectal tumor, including 16 males and 14 females.

Treatment drugs: daily administration of 6 grams of mulberry yellow treatment effect, patients generally reflect pain relief, appetite improvement, weight maintenance, fatigue reduction. In addition, the immune response of patients' lymphocytes (PHA reaction and ConA reaction) was detected, and it was found that the immune response of lymphocytes in the group of taking Sanghuang was almost the same as that of normal people, while the reaction of tumor patients without taking Sanghuang was significantly weakened. This further shows that mulberry yellow can effectively enhance the immunity of patients, so that the symptoms of patients with end-stage tumor can be improved accordingly.

Clinical example of antineoplastic drugs combined with Sanghuang after gastric tumor operation

Researcher: JounYonhun

Research unit: South Korea Zhongnan Medical University

Subjects: 93 patients with end-stage gastric tumor after operation.

Treatment: 5-fluorouracil (5-Fluorouracil) 600mg, an antineoplastic drug, was administered orally to Sanghuang 3.3g daily for more than 2 years.

Treatment effect: during the treatment, 3 cases died of tumor recurrence (3.2% of the total), and the remaining 90 cases (96.8% of the total) remained in good condition. According to the treatment experience of doctors, Sanghuang has an effective inhibitory effect on tumor metastasis in these patients.

Analysis of the effect of Sanghuang on promoting immune recovery in patients with gastric tumor after resection

Researcher: KimJonboku

Research unit: Seoul University

Patients: there were 40 patients with end-stage gastric tumor after gastrectomy, including 26 males and 14 females.

Therapeutic drugs: a single blind trial. The first group was given antineoplastic drugs mitomycin (Mitomycin,MMC) and 5-fluorouracil (5-Fluorouracil), and the second group was given placebo three times a day at the same time as anticancer drugs.

Therapeutic effect: the number of immune T lymphocytes and helper-T lymphocytes was detected in patients undergoing gastrectomy, which was used as an index to evaluate the recovery of immune function. The results showed that the recovery rate of immune function in the group taking Sanghuang was higher than that in the group taking chemical antineoplastic drugs alone.

In the speech of experts at the seminar held on April 14, experts from Xi'an Institute of Microbiology confirmed that Sanghuang showed clear anti-tumor activity in the experiment, and the effect of high dose was good, for liver cancer, intestinal cancer, breast cancer and gastric cancer animals. there are very clear anti-tumor data.

Their experiment verified the observation of the old pharmacist of Hu Qingyu Tangguo. The old pharmacist of Hu Qingyu Tangguo observed that the effect of taking 20 grams of mulberry yellow a day was more obvious than that of taking 10 grams a day.

We visited a family member who took Sanghuang. 'in 2005, my sister found a lump in her left breast and had surgery, and in May 2012, she found it on the right, 'she said.' on July 22, she did surgery in Zhe er, and then she started chemotherapy. She had a severe reaction and had to vomit more than 10 times a night. People in the same ward said that if the wild Ganoderma lucidum went to buy some food, the reaction might be a little less. I think Hu Qingyu Tang is an old drugstore. After going there, the old pharmacist in Hu Qingyu Hall said that wild Ganoderma lucidum was better to eat. Only then did I know that there was mulberry yellow. I started eating immediately after I came back. I had a second chemotherapy 20 days later, vomited once or twice, and then I did chemotherapy again 20 days later. When I did it for the third time, my sister only had a little nausea and did not throw up. When I got to the fourth chemotherapy, I stopped vomiting. In this way, I successfully finished 6 times of chemotherapy, and then I did the tests. The indicators were normal.

Cai Weiming, researcher of Zhejiang Academy of Agricultural Sciences, editor-in-chief of Edible and Medicinal Fungi, vice president of Zhejiang Edible Fungi Association and mulberry expert in our province, collected five wild mulberry germplasm resources from Lishui, Tonglu and Chun'an in 2012. His analysis showed that it was also wild mulberry yellow with short growth year, low polysaccharides, total flavonoids and total triterpenes, long growth years, and high contents of polysaccharides, total flavonoids and total triterpenes. Sanghuang has a definite effect on tumor patients.