Ha Wu Yan discovers cellular molecules that induce the degradation of HIV

Good news came from Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences. The basic immune innovation team of the Institute obtained important findings in the research: endoplasmic reticulum type I α-mannosidase can induce the degradation of HIV envelope glycoprotein, and then inhibit the replication of HIV, which is expected to achieve the goal of treatment. The results were published in a recent issue of the American Journal of Biochemistry. This is the team following last year for the first time revealed the existence of degradation of HIV envelope glycoprotein in the human body after the natural immune pathway, in this area of research and another important research results.

Because HIV infection in the human body after the formation of a latent virus pool in cells, in the interruption of treatment after the rapid release of the virus, resulting in continued infection. Therefore, the clinical treatment of AIDS drugs can only inhibit the growth of the virus, but can not completely eliminate AIDS patients in the body of the virus, resulting in AIDS can not be cured.

Under the leadership of Chief Scientist Zheng Yonghui, the team took inhibiting the function of AIDS envelope protein as the main research direction, and finally made important research progress through unremitting efforts.

According to Zheng Yonghui, the research is not only of far-reaching significance for AIDS treatment, but also has important reference significance for developing broad-spectrum and efficient antiviral methods for treating other viral infections, especially for dealing with new, sudden and highly pathogenic viral infections, such as influenza virus, hepatitis C virus, dengue virus, Middle East respiratory syndrome coronavirus, etc.

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