Drugs for infectious diseases of respiratory system in pigs

Respiratory infectious disease in pigs is a common disease in production. Rhinitis and pneumonia are common symptoms such as coughing, sneezing and dyspnea. Pigs of different ages and breeds can be infected, and the speed of infection is fast and the number is large.

Infectious diseases of porcine respiratory system have the following characteristics: first, the pathogen is complex, often not caused by the same or several bacteria, but closely related to many factors in the environment, only when some environmental, management and feeding factors change, will show clinical symptoms. Second, most of the pathogenic microorganisms causing respiratory infectious diseases in pigs are common bacteria, which invade the injured site and remain and proliferate only when the respiratory tract is injured, and then cause disease to pigs. Third, the occurrence of respiratory infectious diseases is greatly affected by external factors, generally there is no obvious seasonality. In addition to pulmonary filariasis, it occurred or aggravated in late autumn, winter and early spring under the conditions of drastic changes in temperature, muggy, humid, cold, poor ventilation, intensive feeding, management and poor feeding. Fourth, when pigs suffer from respiratory infectious diseases, it is easy to have secondary infection or mixed infection, which aggravates the disease and makes the disease difficult to control. 5. Once infectious diseases of pig respiratory system occur, it is difficult to cure completely and easy to relapse. These characteristics have brought some difficulties to the prevention and treatment of this kind of diseases.

In view of the above situation, at present, a series of comprehensive control measures should be taken to maintain a stable and suitable environment for infectious diseases of pig respiratory system, strengthen feeding management, maintain the integrity of respiratory barrier, reduce stress, and be vaccinated. A series of comprehensive prevention and control measures such as the use of antibiotics. Among them, drug prevention and treatment is an effective measure to prevent and control the disease.

Porcine eperythrozoonosis

Porcine eperythrozoonosis is caused by eperythrozoon parasitic on the surface of red blood cells, plasma and bone marrow of pigs, resulting in acute, febrile, icteric anemia, dyspnea, skin ecchymosis and purplish auricular margin in pigs and finishing pigs. sows have characteristic symptoms such as abortion and stillbirth, which often occur in combination with other diseases and lead to death in severe cases.

Sensitive drugs (1) tetracyclines. Doxycycline hydrochloride (doxycycline), chlortetracycline, oxytetracycline, doxycycline hydrochloride is the most effective. (2) fluoroquinolones. Enrofloxacin, ciprofloxacin. (3) the cool class in the big ring. Tylosin, tilmicosin, Ailexin, Beilimycin. (4) Polyenes. Taimiaocin (taimiaoling, Zhiyuanjing). Florfenicol (florfenicol).

Second, the medication plan (1) cause treatment. Group mixed feeding. Each ton of feed mixed with 150 grams of doxycycline hydrochloride, or 300 grams of chlortetracycline, or 800 grams of oxytetracycline plus 150 grams of arsanilic acid and 1000 grams of sodium bicarbonate (baking soda), fed continuously for 5 days, then the dose was halved, and then used continuously for 2 weeks. The mixed drinking method can be used for lactating pigs and severe non-feeding pigs. That is, add 15 grams of doxycycline hydrochloride and 150 grams of sodium bicarbonate in 100 liters of drinking water for 5 consecutive days. After it can be eaten, the above dose will be reduced by half and mixed feeding for 2 weeks. (2) symptomatic treatment and infusion: the remarkable pathological features of the disease are hypoglycemia and acidosis. Therefore, 10% glucose and sodium bicarbonate injection can be injected intravenously to sick sows and severe pigs. Cardiotonic: each diseased pig was intramuscularly injected with 0.5 grams of ANCA injection. Antipyretic: for high fever (42 ℃), pigs can be intramuscularly injected with analgin. Iron and vitamins: iron salt and vitamin C are added to the feed of diseased pigs.

Porcine mycoplasma pneumonia

Porcine mycoplasma pneumonia caused by Mycoplasma hyopneumoniae (porcine asthma, porcine mycoplasma pneumonia) is a respiratory frothy infectious disease, mostly chronic, the main symptoms are low cough, dyspnea, asthma, body temperature is generally not high. The lesion was characterized by fused bronchopneumonia, with "fleshy degeneration" in the apical lobe, cardiac lobe, middle lobe and anterior margin of the septal lobe.

Sensitive drugs (1) macrolides. Tylosin, tilmicosin, Ailexin. (2) Polyenes. Taimiaocin (Zhiyuanjing). (3) fluoroquinolones. Enrofloxacin, ciprofloxacin, ofloxacin, norfloxacin. (4) tetracyclines. Doxycycline hydrochloride. (5) lincomycin and spiramycin.

2. The most important feature of the drug regimen is that the course of the disease is long, and the pathogen may adsorb to the specific deep tissue and produce escape reaction, so that the drug can not contact the pathogen well and the curative effect is unstable. Therefore, the long-term treatment of group mixed feeding or mixed drinking is a better way to control the disease. (1) 500 grams of tylosin per ton of feed and 150 grams of doxycycline hydrochloride were fed continuously for 5 days, the dose was halved, and then used continuously for 2 weeks. (2) 200 grams of tilmicosin per ton of feed were fed continuously for 2 weeks. (3) mix 60 grams of Ailexin and 300 grams of chlortetracycline (150 grams of doxycycline hydrochloride) in each ton of feed and feed continuously for 7 days. (4) mix 200 grams of tamoxin (Zhiyuanjing) per ton of feed for 7 days, or add 100 grams of this product to 100 liters of drinking water for 7 days, then halve the dose and continue to use it for 1 week or 2 weeks. (5) 150 grams of enrofloxacin or ofloxacin or norfloxacin per ton of feed were mixed for 5 days, then the dose was halved and continued for 1 week or 2 weeks.

Vaccine prevention at present, several types of vaccines can be vaccinated against this disease, such as rabbit attenuated vaccine, acellular attenuated freeze-dried vaccine and inactivated vaccine.

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