Chicken sulfonamides poisoning

Among the sulfonamides, especially those that are easily absorbed in the intestinal tract, such as sulfadiazine (S day), sulfamethazine (SM2), sulfamethoxazine (SMM), sulfaquine (SQ) and sulfamethoxypyridazine (SMP), their therapeutic dose is close to that of poisoning. In the prevention and treatment of parasitic parasitic diseases in poultry, sufficient doses and continuous use of drugs must be used in order to be effective, otherwise protozoa are prone to drug resistance. Therefore, large dosage or long duration, uneven mixing in the added feed and other factors may cause poisoning.

(1) etiology

The use of ① sulfonamides is repeated, resulting in repeated addition.

Due to the careless operation of ②, the amount of additives is too large, or the mixing is not uniform, and the medication time is too long.

After the use of sulfonamides, ③ did not provide adequate drinking water.

(2) characteristics of the disease

① diseased chickens have systemic hemorrhagic changes. The diseased chickens showed depression, anorexia, increased thirst, diarrhea and pale crown. Sometimes the head is swollen blue-purple, which is caused by local bleeding. Prolonged clotting time, granular leukopenia and hemolytic anemia. Some have spasms, paralysis and other symptoms.

The egg production of ② adult diseased hens decreased significantly, the eggshell became thinner and rough, the brown eggshell faded, or laid soft eggs. Some have polyneuritis. After autopsy, the kidney, liver and spleen were all enlarged.

When the content of sulfonamides in ③ muscle, kidney or liver exceeds 20 mg / kg, it can be diagnosed as sulfa poisoning.

(3) Prevention and control measures

The prevention and treatment of ① should give priority to prevention. Select sulfonamides with low toxicity, control the dosage, administration route and course of treatment, and pay attention to increase and ensure the supply of adequate drinking water.

If poisoning occurs in ②, you should immediately stop taking medicine, drink 5% glucose water or 0.5%-1% sodium bicarbonate water, and add 0.5 mg of vitamin K per kilogram of feed or double the vitamin content in the diet; severely poisoned chickens can also be intramuscularly injected with vitamin B121 ~ 2 micrograms or folic acid 50 micrograms 100 micrograms.

Adding appropriate amount of vitamin c to ③ feed can promote the recovery of diseased chickens.