Schisandra chinensis can reverse the multidrug resistance of tumor.
The crude extract of Schisandra chinensis and its active component Schisandrin A can reverse multidrug resistance and greatly improve the sensitivity of tumor cells to antineoplastic drugs. The structure of Schisandrin An is different from the known multidrug resistance reversal agents, so it is a kind of Chinese herbal medicine with development prospect. This is a "new discovery" disclosed in his academic report by Liu Gengtao, a researcher at the Institute of Medicine of the Chinese Academy of Medical Sciences and academician of the Chinese Academy of Engineering, at the recent Guangzhou Pharmaceutical 2006 Cross-Strait Pharmacy (Yangcheng) Forum.
Liu Gengtao pointed out that cancer is one of the biggest killers of human health, and its mortality rate ranks first in China and ranks second in the world. Multidrug resistance of tumor cells is one of the important reasons for the failure of tumor chemotherapy. The so-called "multidrug resistance" refers to the congenital existence of tumor cells or induced by chemotherapeutic drugs to a series of antineoplastic drugs with different structures and mechanisms. Therefore, it is of great clinical value to reverse the multidrug resistance of tumor cells and restore the sensitivity of tumor cells to chemotherapeutic agents.
Academician Liu carried out a series of studies on "reversing drug resistance" of Schisandra chinensis in vitro, nude mice and anti-tumor experiments, which confirmed that the crude extract of Schisandra chinensis and its active component Schisandrin A had obvious effect on reversing multidrug resistance. In the experiment of enhancing the inhibitory effect of the crude extract of Schisandra chinensis and these three drugs on the growth of sarcoma S180 in mice, it was found that the anti-tumor effects of the three drugs were enhanced to a certain extent, and the tumor inhibition rates were 51.66%, 38.11% and 53.05%, respectively. In the mechanism study, Academician Liu found four mechanisms: first, Schisandra chinensis can increase the accumulation of antineoplastic drugs in drug-resistant tumor cells, thus enhancing the curative effect; second, it can inhibit the expression of P-glycoprotein, suggesting that it can play its role at least partly by interfering with the drug efflux pump mediated by P-glycoprotein directly or indirectly; third, it can significantly increase the susceptibility to apoptosis of hepatocellular carcinoma BEL7402 cells induced by adriamycin. Fourth, calcium antagonist VER can partially antagonize the increase of intracellular calcium induced by dihydropyridine calcium agonist BAYK8644, suggesting that Schisandrin itself has no calcium antagonistic activity.
The above studies show that the mechanism of Schisandra chinensis crude extract reversing multidrug resistance is mainly related to the inhibition of P-glycoprotein and the enhancement of antineoplastic drugs to induce apoptosis of drug-resistant tumor cells. Liu Gengtao said that the research results have now applied for patent protection. He believes that Schisandra chinensis is rich in domestic resources and is worthy of further research and development.
- Prev
What is the method of high yield of Schisandra chinensis in two years?
In the process of cultivation of Schisandra chinensis, a single plant and two strips are generally used. If it is well managed, it can grow full at that time, but most of them are half-frame or more than half-frame. Now it is best to plant a single plant and a single vine, and the specific method is to keep half a frame in the first year. In that year, the branches can grow 2 meters, the thickness of the main vine can reach more than 0.4 meters, and the yield per mu can reach more than 400 jin in the second year. In the following spring, reserve vines are selected at the bottom of the main vine and underground stems. The result of double vine in the third year. Another method is close planting, which is planting plants per mu.
- Next
Shaping and pruning methods of Schisandra chinensis
The principles of shaping and pruning are: keeping strong main vines to ensure rational use of space; leaving old and small; leaving medium and long branches, short and basal branches; and getting rid of weak, over-dense and senescent branches. (1) fixed stem: after transplanting, the standard of fixed stem is: leave 2-3 full buds and cut 3-5cm from the ground. The drying time is in the spring of the following year, after the snow melts and before the plant germinates. Leave 2 strong vines after sprouting, no more than 3. After setting, use 2 strands of acrylic wool, one end and tie it to a stick about 10cm.
Related
- Fuxing push coffee new agricultural production and marketing class: lack of small-scale processing plants
- Jujube rice field leisure farm deep ploughing Yilan for five years to create a space for organic food and play
- Nongyu Farm-A trial of organic papaya for brave women with advanced technology
- Four points for attention in the prevention and control of diseases and insect pests of edible fungi
- How to add nutrient solution to Edible Fungi
- Is there any good way to control edible fungus mites?
- Open Inoculation Technology of Edible Fungi
- Is there any clever way to use fertilizer for edible fungus in winter?
- What agents are used to kill the pathogens of edible fungi in the mushroom shed?
- Rapid drying of Edible Fungi