MySheen

Determination of aminophylline tablets

Published: 2024-09-20 Author: mysheen
Last Updated: 2024/09/20, Take 20 tablets of anhydrous theophylline ┄, weigh them precisely, grind them fine, take an appropriate amount (about equivalent to aminophylline lOOmg), put them in a 200ml measuring bottle, add 0.1mol/L sodium hydroxide solution 20ml and water 60ml, shake for 10 minutes to dissolve aminophylline, dilute it with water to scale, shake well. Filter, refine the filtrate 5ml, place it in a 250ml flask, dilute it to scale with 0.01mol/L sodium hydroxide solution, shake well, and use spectrophotometry (page 17, appendix).

Take 20 tablets of anhydrous theophylline ┄, weigh them precisely, grind them fine, take an appropriate amount (about equivalent to aminophylline lOOmg), put them in a 200ml measuring bottle, add 0.1mol/L sodium hydroxide solution 20ml and water 60ml, shake for 10 minutes to dissolve aminophylline, dilute it with water to scale, shake well. After filtration and precision, the filtrate 5ml was taken and placed in a 250ml flask, diluted to scale with 0.01mol/L sodium hydroxide solution, shaken well, and determined by spectrophotometry (page 17, appendix). The absorbance was determined at the wavelength of 275nm, calculated according to the absorption coefficient (E) of C7H8N402.

The fine powder mentioned above (about 0.5g of aminophylline) was precisely weighed by ethylenediamine, dissolved at a low temperature and cooled by adding water 50ml, 8 drops of sodium alizarin sulfonate indicator solution was titrated with hydrochloric acid titration solution (0.1mol/L) until the solution showed yellow. Per lml hydrochloric acid titration solution (0.1mol/L) is equivalent to C2H8N2 of 3.005mg.

 
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