Infectious Canine Hepatitis and its Prevention and Cure

Canine infectious hepatitis is an acute septic infectious disease caused by canine infectious hepatitis virus. The susceptible animals are young dogs under 1 year old, often showing acute necrotizing hepatitis. The disease occurs all over the world and is a common canine disease.

At the initial stage of the disease, the virus mainly exists in the blood of diseased dogs, and then appears in a variety of secretions and feces, and excreted out of the body, causing environmental pollution, and can be excreted with urine from 6 to 9 months after recovery. Sick dogs and poisoned dogs are the source of infection of the disease. Healthy dogs are mainly infected through the digestive tract, but also through the placenta. The virus has strong resistance and can survive for a long time at low temperature. it still has pathogenicity in soil after 10 to 14 days, but heating can kill the virus quickly. According to the epidemic characteristics of ①, it can occur regardless of breed, sex and season. It occurs frequently in winter, and puppies under 1 year old are the most susceptible. ② clinical symptoms, the initial symptoms are similar to canine distemper, depressed spirit, loss of appetite, increased thirst, and even two forelimbs immersed in water binge drinking, which is the characteristic symptoms of the disease. The body temperature of the diseased dog was more than 40 ℃ and lasted for 4-6 days. Common vomiting and diarrhea, vomit and feces with blood in the prognosis is often poor. Most sick dogs have pain in the sword-shaped cartilage. 7-10 days after the disappearance of acute symptoms, the corneal opacity of some dogs showed white or even blue-white corneal pannus, which was called "hepatitis blue eye" and disappeared a few days later. There are bleeding spots on the gums. No secondary infection can return to normal within a few days. Based on this, a preliminary diagnosis can be made, and the diagnosis depends on laboratory tests, such as virus isolation, fluorescent antibody staining and other specificity tests. Prevention and treatment measures: first, do a good job in kennel hygiene, self-breeding, and it is forbidden to mix with other dogs; second, isolate sick dogs and treat them with high immune serum or adult dog serum, once a day, 10: 30 ml each time, intravenous injection of 50% glucose solution 20: 40 ml, vitamin C 250 mg or adenosine triphosphate (ATP) 15-20 mg, once a day for 3-5 days. Oral Gantaile tablets. To control drinking water, 5% glucose saline can be fed every 2 to 3 hours; third, pre-injection, in recent years, the Veterinary University has developed five attenuated canine vaccines (rabies, canine distemper, parainfluenza, infectious hepatitis, parvovirus enteritis) and canine hepatitis and enteritis. The dogs aged 30-90 days were inoculated 3 times, and the dogs over 90 days old were inoculated twice, each time at an interval of 2-4 weeks. The dosage of each injection: two milliliters of five combined vaccines and one milliliter of two combined vaccines can be obtained for one year. The inactivated aluminum hydroxide vaccine of infectious canine hepatitis developed by Nanjing Police Dog Research Institute has a good immune effect on the prevention of this disease. dogs aged 1.5-2 months are vaccinated twice with an interval of 15 days, 1 ml each time, and can obtain immunity for at least 6 months. it has good safety to dogs, and no local and systemic reaction is better than the imported attenuated vaccine of infectious hepatitis in dogs.