Prevention and treatment of pseudorabies in pigs with high fever, anorexia, convulsive ataxia

Porcine pseudorabies is a major infectious disease with high morbidity and mortality in piglets, especially in winter. Sow houses at the peak of delivery are the first to develop the disease, with an incidence rate of 100%. The infected pigs are mainly piglets within 15 days old, and the earliest onset age is 4 days old, with an morbidity of 98% and a mortality rate of 85%. With the increase of age, the mortality rate decreased, and adult pigs became slightly ill, but rarely died. Most sows show transient or subclinical infection but rarely die.

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Porcine pseudorabies is mainly infected by respiratory tract infection. It can also be transmitted through contact with rats, pigs and other infected animal carcasses. It can also be infected through the digestive tract after eating feed contaminated by virus and drinking water. In addition, it can be infected by contact with contaminated vaginal mucosa and semen through damaged wounds and mating. After infection in pregnant sows, the fetus was infected through placenta; 6-7 days after infection in lactating sows, there was virus in milk and lasted for 3-5 days, and suckling piglets could be infected by lactation.

Porcine pseudorabies is mainly characterized by respiratory and neurological symptoms, sudden onset, body temperature rising to more than 41 ℃, mental fatigue, anorexia, vomiting or diarrhea. Symptoms such as ataxia and convulsions occurred within 24 hours, and most pigs died within 24-36 hours after the onset of neurological symptoms. Within 15 days of age, the mortality rate of piglets was nearly 100%, and most of them died in the whole litter. The morbidity decreased after 20 days old, but there was still a high mortality rate.

Prevention and control measures:

1Emergency vaccination. All pigs in pig farms were vaccinated with high quality pseudorabies gene deletion attenuated live vaccine, and the immunization was strengthened once after an interval of 4-6 weeks. Piglets can also be immunized with nasal attenuated live vaccine, and a special nasal drip can be used. If you use a syringe, you should first cover one nostril and give a small amount of nasal drops to the other nostril so that the vaccine can be inhaled into the nasal cavity normally.

2Disinfection. The barracks, sites, roads, etc., are disinfected with 3% caustic soda solution or 1RU 300 compound phenols, compound aldehydes, etc., and overalls, shoes, caps, etc. are soaked in disinfectant or sterilized by high pressure.

(3) strengthen biosafety. Dogs, cats, birds and other animals are strictly prohibited from entering pig farms and strengthening rodent control; foreigners and vehicles are strictly restricted from entering pig farms; it is forbidden to visit houses by personnel in the farm to prevent artificial spread; the carcasses of dead animals, stillbirths, abortion products, other pollutants and excreta are treated innocuously or deeply.

4Prevention and control. In addition to the early use of anti-fake rabies specific serum, there is no special treatment. Therefore, pig farms should effectively implement the policy of "prevention is the first, prevention is more important than treatment" and take comprehensive prevention and control measures.

(5) strengthen biological and veterinary hygiene. Do not mix with cattle, sheep, rabbits, minks and foxes, eliminate feral cats and rats, prohibit dogs and cats from entering the production area, and prevent mutual transmission. Strengthen daily disinfection, feces should be piled up and fermented. When introduction, serological test must be done, and only when negative is confirmed can it be introduced and kept in isolation for 4 weeks.

(6) do well the purification of pseudorabies. When the conditional pig farms were immunized with gE gene deletion vaccine, the breeding pigs were regularly monitored with differential diagnosis kit to eliminate the positive breeding pigs, and the backup breeding pigs were monitored and the positive ones were fattened.