Is Platycodon grandiflorum poisonous?

Platycodon grandiflorum not only can be eaten as a vegetable, but also can be used as medicine. Its roots can be used as medicine, and it has the functions of relieving cough and expectoration, expelling lung, expelling pus and so on. It is produced in most parts of China and does not have any direct relationship with oranges or citrus genera. Let's take a look at whether Platycodon grandiflorum is poisonous.

Is Platycodon grandiflorum poisonous?

Platycodon grandiflorum is non-toxic. Platycodon grandiflorum can stimulate gastric mucosa after taking, the dose is too large, it can cause mild nausea, even vomiting, gastric and duodenal ulcer should not be used with caution, the dose should not be too large.

Toxicity test of Platycodon grandiflorum

Platycodon grandiflorum saponins have hemolysis and can not be used for injection. After oral administration, they are hydrolyzed and destroyed in the digestive tract, that is, no hemolysis. When the mice were given subcutaneous injection, the minimum lethal dose was 770 mg / kg, the half lethal dose of Platycodon grandiflorum decoction was 24 g / kg, and the rabbits were given Platycodon grandiflorum decoction 40 g / kg. All 5 rabbits died within 24 hours, and all survived when the dose was 20 g / kg.

The hemolytic index of Platycodon grandiflorum saponins varied with origin, growth years, collection time and processing methods, ranging from 1VV 100 to 1RU 1000. The hemolytic effect of phloem was 4.4-6.5 times of that of the protoplasm, and the hemolysis of non-peeled Platycodon grandiflorum was slightly greater than that of peeled Platycodon grandiflorum. Therefore, Platycodon grandiflorum can not be injected, the minimum lethal dose of subcutaneous injection of Platycodon grandiflorum saponins in mice is 770 mg / kg, and the median lethal dose of crude Platycodon grandiflorum saponins in mice and rats is 420 mg / kg and 800 mg / kg, respectively. subcutaneous injection was 22.3 mg / kg and 14.1 mg / kg respectively. Intragastric administration of large doses of Platycodon grandiflorum saponins can reflex excite the vomiting center and cause nausea and vomiting.

Efficacy and function of Platycodon grandiflorum

[nature] bitter, bitter, flat.

Lung Meridian.

[efficacy] to clear the lungs, remove phlegm, remove pharynx, expel pus, regulate qi, activate blood circulation, digest food, and calm the nerves.

1, cough phlegm, chest tightness is not smooth: Platycodon grandiflorum dispels bitter diarrhea, release lung qi, expectorant, regardless of cold and heat can be applied. Wind-cold, with perilla, almonds, such as Xingsu San ("differentiation of febrile diseases"). Wind-hot people, with mulberry leaves, chrysanthemums, almonds, such as mulberry chrysanthemum drink ("differentiation of febrile diseases"). If you treat phlegm stagnation chest ruffian, often with Fructus Aurantii.

2. Sore throat and aphonia: Platycodon grandiflorum can relieve evil in the lungs and open pharynx. Where external evil invades the lungs, sore throat and loss of voice, it is often used with licorice and burdock, such as Platycodon grandiflorum decoction (synopsis of the Golden Chamber) and modified Ganju decoction (Medical mind). Treat sore throat, heat toxin Sheng, can be equipped with dry shoot, Ma Bo, Banlangen and so on to clear heat and detoxify pharynx.

3. Lung carbuncle vomiting pus: Campanulum grandiflorum is scattered upward, which can benefit lung qi to expel pus and sputum obstructing the lung. Treat lung carbuncle, cough and chest pain. Expectoration and fishy smell can be used with licorice, such as Platycodon grandiflorum decoction (synopsis of the Golden Chamber). Clinically, it can be equipped with houttuynia cordata, wax gourd kernel and so on to enhance the effect of clearing lung and expelling pus.

4. Platycodon grandiflorum has antitussive effect, anti-inflammatory and immune effect, and its anti-inflammatory intensity is similar to that of aspirin. Water extract can enhance the phagocytosis of macrophages, enhance the bactericidal activity of neutrophils and increase the activity of lysozyme. It has preventive effect on stress ulcer.

5. Platycodon grandiflorum crude saponins have sedative, analgesic and antipyretic effects, as well as lowering blood sugar, lowering cholesterol and relaxing smooth muscle. Platycodon grandiflorum saponins have strong hemolytic effect, but oral administration can decompose and destroy in the digestive tract and lose the hemolytic effect.