Prevention and treatment of Taize's disease in black guinea pigs

Taizer's disease

Tezer's disease is a disease characterized by severe diarrhoea, dehydration and rapid death. The pathogen is Bacillus hairy. The disease occurs in many countries and regions, and the mortality rate is as high as 95%. It is a major threat to the rabbit industry and guinea pigs.

Bacillus hairy is a kind of slender Gram-negative bacteria, which is bundled in the cytoplasm of hepatocytes, smooth muscle, myocardium and epithelial cells. Periodate-Schiff staining, Warthin-Stany staining, Giemsa staining and silver staining are used. It is very difficult to isolate this bacteria, and most researchers believe that the pathogen can not grow on both artificial medium and living medium. It was reported that the bacteria could grow on mouse embryo cells, but lost its ability to cause disease to mice after the second subculture. In recent years, this strain was successfully isolated by culture in yolk sac of chicken embryo. After 32 times of subculture of chicken embryo yolk sac, Taize's disease was replicated in weaned rabbits, and the bacteria was re-isolated from the liver of diseased rabbits. It is believed that the initial isolation of Bacillus hairy by inoculation with chicken embryo yolk sac was not successful because of the growth of intestinal bacteria. For example, when sulfaquinoxaline was added to the drinking water of artificially infected diseased rabbits, the success rate of isolating Bacillus hairy was high by chicken embryo culture. Intestinal bacteria are easy to enter the liver, which makes it difficult to isolate the bacteria. Bacillus hairy can only reproduce in the cytoplasm. In addition, the strain can produce spores, can move, and has pleomorphism. The spore bacteria have strong resistance and can remain contagious in the bottom of the soil for as long as a year.

In addition to rabbits, Taize's disease has been found in many animals, such as mice, rats, hamsters, guinea pigs, muskrats, cats and rhesus monkeys. Because pathogens are difficult to isolate and culture, in many cases, Tazer's disease is mistaken for mucinous enteritis or other similar diseases. The morbidity and mortality of the disease are very high, with the highest incidence in rabbits aged 6 to 12 weeks, but young and adult rabbits before weaning can also be infected with the disease. Bacillus hairy is excreted from the feces of diseased rabbits and pollutes the surrounding environment. Healthy rabbits can be infected after eating. It invades the mucosal epithelium of the small intestine, cecum and colon, and proliferates slowly at the beginning, with little tissue damage and no clinical symptoms, but if it is affected by stress factors such as overheating, overcrowding and operation, the bacteria can multiply rapidly. cause intestinal mucosal and deep tissue necrosis. The bacteria circulate through the portal vein into the liver and other organs, causing serious damage. When sulfonamides are used to treat other diseases, it is easy to lead to the occurrence of this disease because it interferes with the ecological balance of microorganisms in the gastrointestinal tract.

Prevention and cure measures

1. Prevention: strengthen feeding management, improve environmental conditions, disinfect regularly and eliminate all kinds of stress factors. Isolate or eliminate sick rabbits. The rabbit house was completely disinfected and the rabbit excreta was fermented or burned to prevent the spread of pathogens. For the rabbits known to be infected with the disease, the use of antibiotics within the time of stress factors can prevent the occurrence of the disease.

2. Treatment: guinea pigs and rabbits were treated with antibiotics at the initial stage of the disease. Drinking water with 0006% oxytetracycline and 0.01% oxytetracycline has a good effect. Penicillin was injected intramuscularly with 20, 000-40, 000 units per kg body weight, twice a day for 3-5 days. Streptomycin was injected intramuscularly at 20 mg / kg body weight for 3 to 5 days. The effect is more obvious when penicillin and streptomycin are used together. Erythromycin, 10 mg per kg body weight, was taken orally twice for 3 to 5 days. In addition, treatment with chlortetracycline and tetracycline also has a certain effect.

3. If the treatment is ineffective, it should be eliminated in time.