The effect and function of Yangjiao

Sheep horn depression is also known as sheep horn new, sheep horn vine, inverted fishing pen, etc., for the roots or stems and leaves of sheep horn depression of the family Apocynaceae, which is used in medicine to dispel rheumatism, clear channels and collaterals, detoxify sores and kill insects. It has therapeutic effects on rheumatism arthralgia, poliomyelitis sequelae, falling injury, carbuncle, scabies and so on. Let's take a look at the efficacy and effect of sheep horn depression.

The Medicinal effect of Yangjiao

The taste is bitter, cold and poisonous.

The meridians of heart, liver and spleen.

[efficacy] remove rheumatism, clear channels and collaterals, detoxify sores, kill insects, mainly treat rheumatism arthralgia, poliomyelitis sequelae, fall injury, carbuncle, scabies.

Medicinal taboos of Yangjiao

1. "Materia Medica seeks the original": it is poisonous and can be imported.

2. "Lingnan Medicine Collection record": it is highly toxic and does not take the medicine.

The related exposition of Yangjiao

1. "Materia Medica seeks the original": stop itching, treat scabies, heat and poison.

2. "Lu Chuan Materia Medica": relieving sore toxin and removing blood stasis. To treat sore and carbuncle and injury caused by fall.

3. Lingnan Herbal Medicine Chronicles: insecticidal for external use, removing swelling toxin, dredging arthralgia, continuing bones.

4. "Fujian Chinese herbal medicine": dispelling wind and dampness, dredging channels and activating collaterals.

Selection of Medicinal prescription of Yangjiao

1. Treat rheumatism, swelling and pain, sequelae of poliomyelitis, scabies: proper amount of sheep horn twisted leaves, warm washing of decoction.

2. Treat multiple abscesses, tenosynovitis, snakebite, fall fracture: proper amount of sheep horn twisted leaf powder, warm compress with wine.

3, the initial stage of treatment of breast abscess: Yangjiao fresh leaves, brown sugar are smashed together, baking and external application.

Pharmacological effects of Yangjiao

1. The effect on the heart: Yangjiao mixed glycosides can strengthen the cardiac contraction, slow down the heart rate and block the heart in cold-blooded and warm-blooded animals, and have a therapeutic effect on heart failure caused by chloral hydrate, pentobarbital sodium, sodium cyanide, dinitrophenol and so on. it not only enhances myocardial contractility, but also increases output and decreases venous pressure, but has no effect on failure caused by iodoacetic acid.

2. Absorption, accumulation and elimination: the absorption of gastrointestinal tract was slow and irregular, the absorption was the highest at 4 and 5 hours after administration, the accumulation of mixed glycosides was very low, and there was no accumulation at all after 5 days. The liver plays a role in its detoxification. Its destruction in vivo is slightly slower than that of anthocyanin G, and the elimination rate is 0.006 mg / kg / h.

3. Biological potency: the toxicity of mixed glycosides of Rhizoctonia angustifolia is about 1 × 2 less than that of anthocyanin G, and its therapeutic index and safety range are slightly narrower, but from a clinical point of view, the width of the therapeutic dose is wider than that of the latter. Due to different extraction methods and other reasons, the biological potency of each batch of mixed glycosides may be different. Therefore, a standard method must be selected for verification. Another method is the pigeon method is better than the cat method.

4. Other functions

The sedative effect of ①: the mixed glycosides of Rhizoctonia lanceolata have a slightly sedative effect.

Diuretic effect of ②: it showed diuretic effect on anesthetized dogs and normal rats.

The effect of ③ on smooth muscle: in the experiment of rabbit uterus and uterine fistula in vitro and in vivo, it is proved that it is similar to trichosanthin K, has the effect of stimulating uterus, and can increase the tension and movement of isolated intestine.