Prevention and treatment of porcine pseudorabies

Porcine pseudorabies virus is an acute infectious disease caused by pseudorabies virus in a variety of livestock and wild animals. The resistance of the virus is relatively poor, and it is the most stable in a humid environment with a pH of 6: 8. It loses its vitality after 7 days at 4: 37 ℃ and pH 4.3-9.7, and is highly sensitive to drying, especially direct sunlight. Let's take a look at the prevention and treatment of porcine pseudorabies.

Popular characteristics

All lactating livestock are susceptible to pseudorabies and rodents play an important role in the transmission of pseudorabies. Pigs that are not immune and are first infected with pseudorabies can have disastrous consequences and can spread to the whole herd within a week. More than 90% of piglets are infected and die, adult pigs have symptoms of respiratory infection, and pregnant sows have abortions. The virus can be transmitted through placenta, vaginal mucus, semen and milk, often sporadic.

Clinical symptoms

The main symptoms of pseudorabies are body temperature 41.0-42.0 ℃, shortness of breath, refusing to eat, vomiting or diarrhea, death in lethargy, or agitation, foaming at mouth, ataxia, circle turning, convulsion and other neurological symptoms, followed by inhibition, paralysis or paralysis or loss of consciousness, vision, hoarseness, common constipation and respiratory symptoms.

Pathological changes

The pathological changes of pseudorabies pigs were mainly found in non-suppurative encephalitis, cerebral hyperemia, hemorrhage, edema, yellow-white necrotic spots in liver, kidney and heart, pulmonary congestion and edema, common catarrhal and hemorrhagic inflammation in upper respiratory tract, large area hemorrhage in gastric fundus, necrotizing placentitis in aborted sow placenta and blood spots on fetal surface.

Prevention and cure method

There is no specific treatment for porcine pseudorabies, so comprehensive prevention and control measures must be taken. At ordinary times, we should strengthen feeding and management, do a good job of hygiene and disinfection, and do a good job of killing mosquitoes, flies and rodents. Cephalosporins combined with interferon has a certain curative effect when the disease occurs. Eliminating rodents in pastures is of great significance to the prevention of the disease. at the same time, it is necessary to strictly control the entry of dogs, cats, birds and other birds into pig farms, strictly control the flow of personnel, and do a good job in disinfection and serological monitoring. this can also play a positive role in the prevention and control of the disease.

Immune inoculation

1. Back-up pigs should be vaccinated with pseudorabies vaccine at least twice before mating, and gene deficient attenuated vaccine can be used twice.

2. According to the degree of infection in this field, sows should be immunized once or twice in the late stage of pregnancy (20-40 days before delivery or 75-95 days after mating).

3. Inactivated vaccine or gene deficient attenuated vaccine can be used in sows, and gene deficient attenuated vaccine can be used at least once in 2 times of immunization.

4. Pigs with no pseudorabies epidemic in or around the farm can be immunized with an inactivated vaccine after 30 days.

5. Pigs that have experienced an epidemic in or around this farm should be vaccinated with 1 attenuated vaccine at the age of 19 or 23-25 days.

6. Pigs with frequent occurrence should be intranasally injected with gene-deficient attenuated vaccine at the age of 3 days, and the conservation and fattening pigs in the epidemic area or the pig farm with serious epidemic situation should be immunized once 3 weeks after the first immunization.