Side effects of florfenicol

Florfenicol is suitable for poultry infected with bacterial diseases. Although its therapeutic effect is good, it also has a lot of precautions when using it. So what are the side effects of florfenicol?

Side effects of florfenicol

Florfenicol has immunosuppressive effect, which is easy to cause the recombination of cell gene chain and the decrease of body resistance. It also has embryotoxicity and should be used with caution during pregnancy and lactation. This product is mainly used for bacterial diseases of cattle, sheep, pigs, dogs, cats, chickens and fish caused by sensitive bacteria.

Matters needing attention in the use of florfenicol

1. This product should not be used in combination with macrolides, lincoamines and diterpenoid semisynthetic antibiotics-tamoxin.

two。 This product should not be used in combination with β-lactone amines (such as penicillins, cephalosporins) and fluoroquinolones (such as enrofloxacin, ciprofloxacin, ofloxacin, etc.), because this product is a quick-acting bacteriostatic agent to inhibit bacterial protein synthesis, the latter is a quick-acting fungicide in the breeding season. Under the action of the former, bacterial protein synthesis was rapidly inhibited, bacteria stopped growing and multiplying, and the bactericidal effect of the latter was weakened. Therefore, when the treatment needs to play a rapid germicidal effect, it can not be used together.

3. This product cannot be mixed with sulfadiazine sodium by intramuscular injection. Oral or intramuscular administration should not be used in combination with alkaline drugs to avoid decomposition failure. It is also not suitable for intravenous injection with tetracycline hydrochloride, kanamycin, adenosine triphosphate, coenzyme A, etc., so as to avoid precipitation and inefficiency.

4. Intramuscular injection may cause muscle degeneration and necrosis, so it can be injected alternately into the deep muscles of the neck and buttocks, and should not be repeated at the same site.

5. As this product may have embryotoxicity, it should be used with caution during pregnancy and lactation. Poultry is banned during the laying period.

6. In the prevention and treatment of porcine respiratory syndrome (PRDC), florfenicol is recommended to be used in combination with amoxicillin, florfenicol and tylosin, florfenicol and tylosin, but this method is inappropriate because from a pharmacological point of view, florfenicol and tylosin cannot be used together. But florfenicol can be used in combination with tetracyclines such as doxycycline.

7. This product has hematological toxicity and does not cause irreversible bone marrow aplastic anemia, but reversible erythropoiesis inhibition is more common than chloramphenicol. Animals with severe impairment of immune function or vaccination period are prohibited. 8. This product has a strong immunosuppressive effect, about 6 times stronger than chloramphenicol.

9. Long-term use may cause digestive disorders and vitamin deficiency or symptoms of double infection.

10. In the prevention and treatment of pig disease, care should be taken, drugs should be given in accordance with the prescribed dose and course of treatment, and should not be abused to avoid adverse consequences.

11. Animals with renal insufficiency should reduce or prolong the interval between administration.

twelve。 When the drinking water agent is given, pay attention to the concentration of the ratio, and only the drinking water containing drugs is used as the only source of water for livestock and poultry. 13. This product is a special drug for animals and does not form cross-resistance with human beings. It is used within the therapeutic dose and has no toxic side effects. It is not harmful to the environment. According to the FDA of the United States, the withdrawal period is 28 days. The relevant provisions of China's Ministry of Agriculture (tentatively): livestock and poultry for 30 days; broilers for 10 days; aquatic products for 7 days; pigs of different ages and weights can be used, but fattening pigs had better not be used, let alone long-term use, to avoid drug residues.

The above is about the introduction of florfenicol, I hope it can help you.