Does African classical swine fever infect cattle and sheep?

African classical swine fever is a hot topic now, and many farmers have suffered from it and suffered losses to varying degrees. So does African classical swine fever infect cattle and sheep? Let's have a look!

I. does African swine fever infect cattle and sheep?

African classical swine fever is not currently transmitted to cattle and sheep. Classical swine fever is an acute and infectious febrile disease, and there is no effective treatment at present. And there is no vaccine to prevent, once the disease, the mortality rate is extremely high.

II. Vaccine development

On May 24, 2019, the African classical swine fever vaccine independently developed by Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences achieved phased results. China has made five major advances in the development of classical swine fever vaccine in Africa:

One is to isolate the first African classical swine fever virus in China. The virus cell isolation and culture system and animal infection model were established, and its biological characteristics such as infectivity, pathogenicity and transmission ability were studied systematically.

The second is the creation of African classical swine fever vaccine candidates, laboratory studies have proved that two vaccine candidates have good biological safety and immune protection effect.

Third, the two candidate vaccine strains have strong genetic stability in vitro and in vivo. When the two candidate vaccine strains were continuously passaged in primary cells in vitro, there was no significant change in their biological characteristics and genome sequence, and no obvious virulence reversion was found in pigs.

Fourth, the minimum protective inoculation dose is defined, which proves that high-dose and repeated-dose vaccination is safe.

Fifth, the preliminary completion of the pre-clinical pilot product process research, the establishment of two candidate vaccine production seed bank, the preliminary completion of vaccine production seed batch purity and exogenous virus test, the preliminary optimization of cell culture and freeze-drying process of candidate vaccine.