How to prevent and cure Klebsiella in cultured nutria

Klebsiosis, also known as multiple abscess, is a sporadic or endemic chronic infectious disease caused by Klebsiella pneumoniae. Pathogen and Epidemiology cover the bacteria are widely distributed in soil, water, respiratory tract and digestive tract of human and animals, and can cause disease in human and fur animals, livestock, poultry and other animals. The disease mostly occurs in summer and autumn, especially in young mice. The bacteria is pleomorphic in the culture medium, but it is mostly short and thick oval bacilli in the diseased material (1mur2 microns long, 0.5-0.8 microns wide), scattered or arranged in pairs, no flagella, no movement, and can form a large thick capsule, which is 3 times that of the bacteria. But after long-term culture, it loses its thick capsule and has pili. Gram staining is negative and often shows bipolar staining. Milky white, moist, shiny and translucent mucilaginous round colonies were formed on ordinary Agar medium. Continue to culture, some fuse each other into mucus, hook with the inoculation ring, lead to silk; after 4 days of oblique Agar culture, the fungus moss flows to the lower part of the slope in honey shape; cultured in broth for a few days, it grows into mucus. (clinical symptoms) most of the disease shows chronic process, and the early clinical symptoms are not obvious, only localized round or oval abscess occurs in the body, and the abscess often occurs in the hindlimb, tail, submandible, forelimb and back, sometimes occasionally at the end of the nose. Some abscesses burst out of a thick gray pus, its smell fishy. Autopsy showed abscesses with different hardness from soybeans to eggs; incision observation showed that there was gray-white thick pus in the middle of the abscess and surrounded by connective tissue. The affected mice gradually lose weight, lose appetite or abolish in the middle and later stage of the disease, and young mice often have hindlimb paralysis. The diagnosis can be made initially according to the typical symptoms, but the diagnosis needs further bacteriological examination and biochemical experiments.

(there is no effective Klebsiella pneumoniae vaccine for prevention and treatment at present. Strict implementation of veterinary hygiene system, strengthening the hygiene and disinfection of rat houses, especially ensuring the cleanliness of bath water and preventing trauma of rodents, and strict quarantine are important measures to prevent the occurrence of this disease. If Klebsiella has occurred, local and systemic therapy should be taken at the same time.

① local therapy: cut open the abscess, drain the abscess, wash it with 3% hydrogen peroxide and 0.1% Rivernol, then apply 3% iodine, and finally spread anti-inflammatory powder. The tail and hind legs can be bandaged. In this way, discharge pus and wash once a day, and be careful not to let the affected rats enter the pool.

② systemic therapy: furazolidone was mixed with 0.5 tablets / concentrate twice a day, while chloramphenicol 0.5 ml / mouse was injected intramuscularly twice a day for 6 days.