Prevention and treatment of Vibrio disease in cultured puffer fish

[symptoms of globefish vibrio disease] the pathogen is Vibrio, whose developmental temperature is 101Z-35C, and the optimum temperature is about 25C; the developmental salinity is 0.5%-6%, even up to 7%, and the optimum salinity is about 1%; the pH value of development is 6 min 8, and the optimum temperature is about 8. The digestive tract of the diseased fish is bleeding, inflamed, the anus is red, the liver has bleeding spots, and the body surface bleeds and turns red; after that, the dermis is ulcerated, the base of each fin is congested and red, the anus is red and swollen, exophthalmos, intraocular bleeding or bubbles are produced, or the eyeballs become white and turbid. The internal organs and muscle tissue have diffuse or punctate bleeding, the intestine has severe inflammation, and the intestinal mucosa decays and falls off to form yellow or yellowish-red mucus. Bleeding and even necrosis of liver, kidney and spleen.

[prevention and control methods of globefish vibrio disease] (1) Preventive measures of globefish vibrio disease: ① operation is careful to prevent fish injury; ② stocking density should not be too high; ③ maintains good water quality and does not feed rotten and deteriorating feed; ④ uses fresh water or 4% concentrated salt water to remove marine fish surface parasites, antibiotics should be added to prevent and control bacterial infection; ⑤ found that individual diseased fish were immediately fished out, isolated, reared or destroyed; ⑥ for artificial immunity. Before the disease season, every kilogram of fish was fed with 4 grams of formalin inactivated Vibrio anguillarum vaccine for 15 consecutive days. This method is only effective in experiments, and its use in production needs further study. (2) treatment of puffer fish vibrio disease: ① pure powder of antibiotics such as oxytetracycline hydrochloride, tetracycline, chloramphenicol or chlortetracycline, 50ml 70mg per kg of fish per day ② sulfamethazine, or 4-sulfonamide-2.6-dimethylpyrimidine (long-acting sulfonamide), or 4-sulfonamide-6-methoxazine (bacteria sulfonate, long-acting sulfonamide C) and other sulfonamides powder, 200mg per kilogram of fish per day, mixed into the feed for 7 days, but the fish did not eat when the water temperature was below 15 ℃, then oral administration was invalid; ③ furazolidone was sprinkled throughout the pool at a concentration of 0.5ml mg / L.